Metabolism ntawm arginine
1. Cov txheej txheem metabolic ntawm arginine hauv lub cev yog los tsim cov tshuaj xws li urea, ornithine, proline, polyamine, glutamic acid thiab glutamate los ntawm arginase. Cov tshuaj no ua lub luag haujlwm tseem ceeb hauv kev noj zaub mov zoo thiab lub cev muaj zog hauv cov txheej txheem ntawm tib neeg lactation, kev loj hlob, kev loj hlob thiab kho cov ntaub so ntswg. Arginine tuaj yeem tsim ornithine thiab creatine acetate los ntawm txoj kev arginine / glycine transaminase, thiab tom kawg tuaj yeem ua methylated hauv daim siab los tsim creatine, uas yog qhov tseem ceeb ntawm creatine hauv lub cev.
The immunomodulatory effect of arginine in the body is mainly through two metabolic pathways: the "arginase" pathway and the "NO" pathway.
2. Mammalian arginase, suav nrog arginase I thiab arginase II, ob qho tib si ua rau kev hloov pauv ntawm arginine rau ornithine thiab urea.
Arginase I tau qhia ntau heev nyob rau hauv hepatocytes, thiab arginase II yog ib tug mitochondrial enzyme tsuas yog qhia nyob rau hauv lub raum, hlwb, lub mis, thiab macrophages. Arginine hloov mus rau ornithine los ntawm arginase. Ornithine yog lub hauv paus ntawm urea thiab polyamine, thiab ua lub luag haujlwm tseem ceeb hauv lub voj voog urea thiab tsim ntawm polyamine.
3. Raws li ib tug precursor ntawm nitric oxide, arginine hloov mus rau NO thiab citrulline nyob rau hauv qhov kev txiav txim ntawm nitric oxide syntheses (NOS) nyob rau hauv tib neeg lub cev. TSIS muaj peev xwm tswj tau vascular tone, tswj kev tiv thaiv kab mob, thiab txo cov plab hnyuv siab raum Nws plays lub luag haujlwm hauv kev puas tsuaj ntawm cov kab mob mucosa.
Arginine muaj cov nyhuv secretory ntawm ntau yam ntawm cov qog endocrine, tuaj yeem txhawb kev tso tawm ntawm pituitary txoj kev loj hlob hormone thiab prolactin, thiab txhawb kev tso tawm ntawm insulin, somatostatin, pancreatic polypeptide, thiab lwm yam ntawm pancreatic, yog li ua rau muaj kev tiv thaiv kab mob tsis ncaj ncees.
Arginine is not only a conditionally essential amino acid, but more importantly, it has immune-enhancing and opsonizing effects. Arginine plays an important role in protein anabolism, polyamine and nitric oxide synthesis, and these products are closely related to the body's immune function. Therefore, the application of arginine has received extensive attention in the study of immune nutrition.