Phytosterols - lub nemesis ntawm cov roj cholesterol siab

Raws li tib neeg txoj kev ua neej nyob mus ntxiv, lawv nyiam noj cov zaub mov muaj calorie ntau ntau, cov zaub mov muaj roj, thiab cov khoom noj uas muaj cov roj cholesterol yog cov ua txhaum ntawm cov kab mob plawv.

Thaum ntxov li xyoo 1950,phytosterolsRaws li chav kawm ntawm cov khoom ntuj tsim, tau lees paub tias muaj lub cev ua haujlwm ntawm inhibiting qhov nqus ntawm cov cholesterol hauv cov hnyuv thiab txo cov roj cholesterol. Nws yog dav faib nyob rau hauv cov xwm thiab yog ib feem ntawm cov cell membranes nyob rau hauv cov nroj tsuag. Nws kuj yog ib qho precursor rau synthesis ntawm ntau yam tshuaj hormones, vitamin D, thiab steroid compounds. Muaj ntau ntau hom tshuaj ntsuab sterols, feem ntau suav nrog 4 methyl-free sterols: stigmasterol, -sitosterol, campesterol, thiab rapeseed sterol.

Qhov chaw

Phytosterols yog dav pom nyob rau hauv cov hauv paus hniav, stems, nplooj, txiv hmab txiv ntoo, thiab noob ntawm cov nroj tsuag, thiab lawv cov ntsiab lus txawv nyob rau hauv ntau hom nroj tsuag. Phytosterols feem ntau yog muab los ntawm cov roj zaub, nplej, txiv hmab txiv ntoo, thiab zaub. Cov saturated phytosterols tau noj tsawg dua, thiab lawv tsuas yog los ntawm pob kws, nplej, rye, thiab mov. Tag nrho cov roj zaub muaj sterols, tab sis kev ua cov roj ntau dua (xws li refining, decolorization, thiab deodorization) zoo heev txo cov ntsiab lus ntawm sterols hauv cov roj zaub.

Qauv

Phytosterols yog ib chav kawm ntawm cov tshuaj nrog cyclopentane perhydrophenanthrene raws li cov pob txha (tseem hu ua steroid nucleus). Lawv muaj nyob hauv cov xeev dawb lossis khi hauv qhov xwm txheej thiab muaj lub luag haujlwm tib yam li cov roj cholesterol hauv cov tsiaj. Phytosterols kuj ua lub luag haujlwm hauv stabilizing cell membranes hauv cov nroj tsuag. Tam sim no, ntau tshaj 40 hom phytosterols tau lees paub, ntawm cov -sitosterol, stigmasterol, thiab campesterol yog cov tseem ceeb. Cov qauv ntawm cov sterols no zoo ib yam li cov roj cholesterol, thiab lawv txhua tus muaj nyob rau ntawm 4-methyl-free sterols. Lawv muaj cov qauv chiral tib yam, thiab qhov sib txawv ntawm cov qauv tsuas yog cov saw hlau sab, tab sis nws yog qhov sib txawv me me ntawm cov saw hlau sab uas ua rau lawv lub cev sib txawv heev.

Cov khoom

Phytosterols yog cov khoom muaj nyob hauv cov nroj tsuag, zoo ib yam li cov tsiaj sterols xws li cov roj cholesterol. Sterols muaj nyob hauv cov nroj tsuag hauv plaub hom, uas yog lub xeev dawb, sterol esters, sterol glycosides thiab acylated sterol glycosides. Dawb sterols thiab sterol esters yog soluble nyob rau hauv non-polar cov kuab tshuaj xws li n-hexane, thaum steryl glycosides thiab acylated steryl glycosides xav tau polar modifiers kom yaj. Feem ntau phytosterols yog cov khoom, xws li sitosterol, campesterol, thiab stigmasterol. Qhov loj ntawm sab saw, qhov muaj zog ntawm hydrophobicity ntawm phytosterol, thiab ob daim ntawv cog lus ntawm sab saw ua rau sterol hydrophilic.

1. Sib tw rau cov roj cholesterol transmembrane transporters - intracellular thiab extracellular flow

Ob leeg cholesterol thiab phytosterols yog cov dej-insoluble. Lawv tsuas tuaj yeem nqus tau los ntawm lub cev tom qab tau yaj hauv micelles. Vim lawv cov qauv zoo sib xws, phytosterols tuaj yeem sib tw nrog cov roj cholesterol kom nkag mus rau hauv cov micelles sib xyaw; Lub peev xwm ntawm micelles kom yaj hydrophobic molecules yog qhov tseeb. Txij li thaum phytosterols yog hydrophobic ntau dua li cov roj cholesterol, cov qub tuaj yeem hloov cov roj cholesterol hauv cov micelles sib xyaw thiab nkag mus rau cov micelles sib xyaw.

Hauv cov ntsiab lus, phytosterols txo cov solubility ntawm cov cholesterol hauv cov micelles sib xyaw.

2. cuam tshuam cov cholesterol los tsim chylomicrons

Cov roj (cholesterol) nkag mus rau hauv cov hnyuv me me epithelial hlwb yog esterified los tsim cov cholesterol esters nyob rau hauv qhov kev txiav txim ntawm ACAT2, thiab tom kawg cov ntaub ntawv chylomicrons nrog triglycerides, apolipoproteins, thiab lwm yam. Phytosterols tuaj yeem tuav cov chaw sib khi uas yuav tsum tau ua rau ACAT2 rau catalyze cov roj esterification, thiab txo cov roj esterification. Kev ua haujlwm ntawm ACAT2 rau cov roj cholesterol los ntawm kev sib tw inhibition, yog li inhibiting qhov nkag ntawm cov roj cholesterol esters rau hauv chylomicrons thiab tso tawm rau hauv lymph, yog li txo qhov nqus ntawm cov cholesterol hauv tib neeg txoj hnyuv.

3. Kev tswj cov roj cholesterol nqus tau zoo ntawm qib caj ces

Phytosterols tuaj yeem txo cov roj cholesterol ester tsim hauv plab hnyuv los ntawm kev sib tw rau cov chaw thauj khoom (NPCIL1), thiab ABCG5 / ABCG8 qhia inhibits cholesterol synthesis hauv daim siab cov ntaub so ntswg thiab txo cov roj cholesterol ester synthesis, yog li txo cov roj cholesterol nqus.

Ib tug loj tus naj npawb ntawm cov hauj lwm tau luam tawm nyob rau hauv daim ntawv thov ntawm phytosterols, npogtshuaj, tshuaj pleev ib ce, khoom noj khoom haus (xws li aviation zaub mov), kho qhov muag khoom, pub, xim, xim, resin, papermaking, textiles, tshuaj tua kab herbicides, thiab lwm yam.

Tam sim no, feem ntau siv dav hauvtshuaj kho mob, qhov twg phytosterols yog siv los ua raw cov ntaub ntawv rau cov tshuaj hormone steroid, tshuaj txo cov roj cholesterol, tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob, thiab lwm yam.

Daim ntawv thov sib txawv hauvteb zaub movfeem ntau yog cov khoom siv ua haujlwm rau kev tiv thaiv kab mob plawv. Tam sim no, kev sib raug zoo ntawm qhov sib ntxiv thiab muaj pes tsawg leeg ntawm phytosterols thiab cov khoom xyaw tseem ceeb ntawm cov khoom noj (xws li muaj pes tsawg leeg thiab cov ntsiab lus ntawm fatty acids) tau pib tsim.

Cov khoom noj tshiab "phytosterols" tsis ntev los no tau pom zoo los ntawm Ministry of Health ntawm Tuam Tshoj yog hu ua "tus yuam sij rau lub neej" thiab "cov hlab ntsha ntawm cov hlab ntsha" los ntawm Suav thiab txawv teb chaws cov kws tshaj lij. Kev sib xyaw ua ke ntawm "phytosterols" thiab mis nyuj, lub npe hu ua "tus huab tais ntawm kev noj haus", tau ua lub luag haujlwm hauv kev tiv thaiv thiab kev sib koom tes ntawm kev kho mob plawv thiab cerebrovascular kab mob - txhawb kev tsim cov fibrinolytic activating factor, raws li ib tug fibrinolytic trigger, ua si ib lub luag haujlwm hauv kev tiv thaiv thiab kev sib koom tes ntawm kev kho mob thrombosis. Tiv thaiv kom tsis txhob nqus cov roj cholesterol thiab khaws cov ntshav lipids, kom cov roj cholesterol ntau dhau thiab cov lipids hauv cov ntshav tau tawm hauv lub cev nrog cov zis thiab quav, uas ua lub luag haujlwm tiv thaiv thiab tswj kev kho mob thiab cov tsos mob xws li kub siab thiab hyperlipidemia. Kev haus dej mus ntev ua rau kom cov hlab ntsha elasticity thiab txo qhov tshwm sim ntawm cov kab mob plawv thiab cerebrovascular.

Nyob rau hauv xyoo tas los no, vim qhov kev tshawb pom ntawm thermal stability ntawm cov nroj tsuag sterols thiab lawv cov antioxidant thiab anti-polymerization muaj peev xwm, cov kev taw qhia ntawm cov nroj tsuag sterols nyob rau hauv lubfrying roj kev lag luamtsis nyob deb. Cov kev tshawb fawb tau nce qib thiab cov qauv ntawm kev sib raug zoo ntawm kev noj zaub mov, noob caj noob ces, thiab kab mob qhia tau tias muaj ib hnub yav tom ntej, RDA cov lus pom zoo noj zaub mov zoo nrog rau cov nroj tsuag sterols thiab lawv cov khoom yuav raug hloov kho kom haum rau tib neeg. Cov kev tshawb fawb tau nce qib thiab cov qauv tseem yuav qhia meej txog qhov cuam tshuam ntawm cov nroj tsuag sterols ntawm cov noob qhia ntawm cov tsiaj thiab cov nroj tsuag, thiab kev ntxub ntxaug ntawm cov nroj tsuag sterols tiv thaiv cov cholesterol hauv tib neeg cov khoom noj.

Hauv kev tshawb fawb txog kev siv pub mis, nws tau pom tias cov nroj tsuag sterols tuaj yeem txhawb kev noj qab haus huv thiab tsim cov tshuaj hormones cog hauv dej, uas yog cog sterol-ribonucleoprotein complexes. Qhov kev ua haujlwm no tuaj yeem ua rau muaj kev ruaj ntseg ntawm thawj cov tshuaj hormones cog rau qhov kub thiab txias (xws li tus tsiaj lub cev kub tom qab nkag mus rau hauv lub cev) thiab decomposition hauv cov tsiaj lub cev, txhawb cov synthesis ntawm cov tsiaj protein, thiab muaj txiaj ntsig zoo rau kev noj qab haus huv thiab kev loj hlob ntawm cov tsiaj.

Phytosterols yog insoluble nyob rau hauv dej, thiab lawv solubility nyob rau hauv cov roj kuj yog heev txwv, uas zoo heev txwv lawv daim ntawv thov. Esterification ntawm phytosterols rau hauv phytosterol esters yog ib qho ntawm cov kev hloov kho tseem ceeb. Cov rog solubility ntawm phytosterols zoo dua. Qhov nqus ntawm esterified phytosterol esters yog siab dua li ntawm phytosterols, thiab nws muaj cov txiaj ntsig tseem ceeb ntawm cov roj cholesterol.

HSF Biotechnologyinvented lub membrane tshuaj tiv thaiv coupling sib cais tshuab kom tsis txhob siv cov kuab tshuaj thiab catalysts nyob rau hauv cov txheej txheem ntawm manufacturing phytosterol esters. Hauv xyoo 2014, nws tau tsim thawj cov kab ntau lawm hauv tsev ntawm phytosterol esters, paub txog kev tsim khoom hauv tsev ntawm phytosterol esters. hloov. Nyob rau hauv tib lub xyoo, LowChol ™ hom tau tsim ib tug series ntawm cov khoom, nthuav dav daim ntawv thov ntawm cov nroj tsuag sterols nyob rau hauv lub teb ntawm roj thiab tshuaj pleev ib ce. Yuav kom ua tau raws li cov dej-solubility yuav tsum tau ntawm phytosterol esters,HSF Biotech tau tsim LowChol™-W dej-soluble phytosterol esters, nqa lub zog tshiab rau cov khoom tsim xws li cov khoom siv mis nyuj, dej haus, thiab dej haus ua haujlwm. Tam sim no, HSF LowChol ™ cog sterol ester series cov khoom tau siv thiab lees paub los ntawm ntau tus neeg siv khoom lag luam paub zoo hauv tsev thiab txawv teb chaws.

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