Kev laus ntawm daim tawv nqaij yog tshwm sim los ntawm ntau yam ntawm sab hauv thiab sab nraud. Nws yog tus cwj pwm los ntawm degeneration ntawm keratinocyte muaj nuj nqi, slowed epidermal renewal, txo barrier muaj nuj nqi, thiab tsis muaj peev xwm los kho kev puas tsuaj. Lub dermis muaj kev txo qis hauv fibroblast suav, nrog rau kev ua haujlwm poob qis thiab txo qis kev sib txuas ntawm collagen thiab extracellular matrix. Qhov no tshwm sim raws li hyperpigmentation, wrinkles, sagging, thiab dilated cov hlab ntsha. Nyob rau hauv xyoo tas los no, kev siv cov khoom noj hauv qhov ncauj los txhim kho daim tawv nqaij zoo li qub. "Nutricosmetics" yog ib hom khoom noj qab haus huv uas txhim khu kev ntxhib los mos thiab pom ntawm tib neeg cov tawv nqaij, plaub hau, thiab rau tes.
Cov tawv nqaij laus
Kev laus ntawm daim tawv nqaij tuaj yeem faib ua ob hom: ① Intrinsic tawv nqaij laus: Nws nce mus rau lub hnub nyoog, ua rau poob ntawm epidermal thiab dermal cell muaj nuj nqi thiab txo qis hauv extracellular matrix, ua rau cov kab zoo thiab thinning ntawm daim tawv nqaij. ② Extrinsic daim tawv nqaij laus: Qhov no feem ntau yog tshwm sim los ntawm kev yees duab, tab sis tej yam xws li huab cua paug, haus luam yeeb, haus cawv, thiab kev ntxhov siab ntawm lub hlwb kuj ua rau nws. Nws ua rau degeneration thiab degradation ntawm dermal collagen fibers, txawv txav ntawm elastin nyob rau hauv papillary txheej, thiab inflammatory kev hloov, ua rau sib sib zog nqus wrinkles, daim tawv nqaij laxity, thiab pigmentation. Ob hom kev laus ntawm daim tawv nqaij feem ntau tshwm sim ib txhij, nrog rau cov kev hloov tseem ceeb tshaj plaws nyob rau hauv lub dermis. Wrinkles thiab txo elasticity yog qhov tshwm sim ntawm kev loj hlob atrophy ntawm dermis. Intrinsic thiab extrinsic tawv nqaij laus yog txuam nrog tiam ntawm reactive oxygen hom (ROS) los ntawm oxidative metabolism thiab raug rau ultraviolet hluav taws xob (UV). Kev sib sau ntawm ROS thaum kawg ua rau DNA puas tsuaj, inflammatory cov tshuaj tiv thaiv, depletion ntawm antioxidants, thiab zus tau tej cov matrix metalloproteinases (MMPs) uas degrade collagen thiab elastin. Yog li ntawd, ROS tsim yog ib qho tseem ceeb mechanism ntawm daim tawv nqaij laus.
Mechanisms ntawm Yuav Ua Li Cas Beauty Supplements Improve Skin Aging
Qee cov khoom xyaw uas muaj cov tshuaj antioxidant tuaj yeem cuam tshuam ncaj qha rau ntawm daim tawv nqaij los ntawm cov neeg xa xov thib ob lossis, thaum lub sijhawm zom zaub mov, dhau los ntawm cov hnyuv mucosal barrier thiab ncav cuag ntau cov ntaub so ntswg hauv lub cev, suav nrog daim tawv nqaij. Cov kab mob bioactive no tuaj yeem faib thoob plaws txhua qhov ntawm daim tawv nqaij (epidermis, dermis, rog subcutaneous) thiab qog sebaceous. Cov txheej txheem los ntawm qhov ncauj kev zoo nkauj tshuaj tiv thaiv kev laus ntawm daim tawv nqaij yog raws li nram no:
- Tiv thaiv DNA thiab mtDNA puas.
- Clearance ntawm oxygen dawb radicals.
- Anti-inflammatory teebmeem.
- Inhibition ntawm glycation.
Common kev zoo nkauj ntxiv
- Collagen
Collagen yog ib qho protein uas tshwm sim uas tshwm sim li ntawm 70% ntawm qhov hnyav qhuav ntawm tib neeg dermis. Nws, nrog rau elastic fibers thiab hyaluronic acid, tsim lub ntsiab yam ntxwv ntawm lub extracellular matrix nyob rau hauv lub dermis. Collagen feem ntau muaj rov ua ntu zus ntawm glycine-proline-hydroxyproline, uas tsim ib qho tshwj xeeb triple helix qauv. Qhov ncauj noj collagen feem ntau yog muab los ntawm daim tawv nqaij porcine, bovine daim tawv nqaij, thiab cov leeg, thiab tau ua tiav rau hauv cov khoom noj khoom haus hauv daim ntawv denatured (gelatin) lossis enzymatically hydrolyzed daim ntawv (collagen peptides, CP). Hauv txoj hnyuv, CP yog zom rau hauv dipeptides (proline-hydroxyproline) lossis tripeptides (glycine-proline-hydroxyproline), uas tau nqus mus rau hauv cov hlab ntsha los ntawm cov protein oligopeptide transporter thoob plaws hauv plab hnyuv mucosa thiab tuaj yeem nyob hauv daim tawv nqaij mus txog 96 teev.
- Hyaluronic acid (HA)
HA yog ib qho uas tsis yog-sulfated glycosaminoglycan muaj li ntawm cov chav nyob ntawm D-glucuronic acid thiab N-acetyl-D-glucosamine. Raws li ib feem tseem ceeb ntawm cov extracellular matrix nyob rau hauv daim tawv nqaij, HA yog tam sim no nyob ib ncig ntawm thiab nyob rau hauv lub hlws ris ntawm collagen thiab elastin fibers, pab tswj cov qauv tsim nyog ntawm collagen thiab elastin. Hauv kev laus ntawm daim tawv nqaij, qhov tsis muaj HA yuav ua rau muaj kev puas tsuaj ntawm collagen thiab elastin fibers, uas ua rau pom cov kab zoo, wrinkles, thiab tob zuj zus ntawm nasolabial folds [21]. HA muaj peev xwm khi dej kwv yees li 1,000 zaug nws qhov hnyav, uas ua rau nws ua kom cov tawv nqaij zoo, yog li txo qhov tsim ntawm wrinkles, txhim kho qhov sib sib zog nqus wrinkles, thiab txo qis wrinkles uas twb muaj lawm.
HA yog tam sim no siv nyob rau hauv hydrogels thiab dermal fillers, thiab nws cov tshuaj pleev ib ce muaj feem xyuam rau inducing ntaub so ntswg li, txhim kho daim tawv nqaij hydration, thiab stimulating collagen synthesis.
- Astaxanthin (ASX)
Astaxanthin yog ib qho tshuaj tiv thaiv kab mob antioxidant uas ua rau muaj zog tiv thaiv antioxidant los ntawm kev tshem tawm cov dawb radicals. Nws muaj peev xwm tshem tawm singlet oxygen yog kwv yees li 1, 000 npaug ntawm coenzyme Q10. Kev tshawb fawb hauv vitro thiab hauv vivo tau pom tias ASX ua lub luag haujlwm hauv kev kho thiab tiv thaiv kev laus ntawm daim tawv nqaij. ASX tswj cov tawv nqaij noj qab haus huv thiab teb rau cov tawv nqaij puas tsuaj vim nws cov tshuaj tua kab mob antioxidant, tiv thaiv kab mob, tiv thaiv kab mob, thiab kho DNA.
- Carotenoids
Carotenoids yog ib chav kawm ntawm cov lipophilic molecules dav dav hauv qhov xwm txheej. Lawv yog synthesized los ntawm cov nroj tsuag, algae, fungi, thiab kab mob. Cov hom carotenoids tseem ceeb muaj xws li -carotene, lycopene, lutein, thiab zeaxanthin, uas muab ntau yam xim xws li liab thiab txiv kab ntxwv rau zaub thiab txiv hmab txiv ntoo. -carotene yog cov carotenoid ntau tshaj plaws nyob rau hauv cov khoom noj mis nyuj thiab muaj peev xwm inhibit singlet oxygen thiab scavenge dawb radicals. Kev tshawb fawb tau pom tias -carotene (nrog rau lwm cov carotenoids) tuaj yeem txo cov noob qhia ntawm hydrogen peroxide thiab superoxide dismutase hauv tib neeg dermal fibroblasts raug UVA hluav taws xob.
- Coenzyme Q10
Coenzyme Q10 yog ib qho endogenous lipophilic compound. Nws muaj nyob rau hauv peb hom: ubiquinone, semiquinone, thiab ubiquinol. Ubiquinone yog hom tsiaj uas muaj ntau tshaj plaws hauv tib neeg thiab tsiaj tsiaj. Raws li cov tshuaj antioxidant, Coenzyme Q10 tuaj yeem tiv thaiv kev ua haujlwm ntawm cov kab mob inflammatory los ntawm kev tshem tawm cov dawb radicals.
Nyob rau hauv xyoo tas los no, cov kev tshawb fawb tseem tau lees paub cov txiaj ntsig antioxidant ntawm Coenzyme Q10, uas tuaj yeem tswj hwm lub zog ntawm tib neeg keratinocytes thiab ua kom rov qab los ntawm ATP qib hauv irradiated tib neeg fibroblasts. Cov kws tshawb fawb ntseeg tias daim tawv nqaij txwv tsis pub nkag mus rau cov tshuaj pleev ib ce Coenzyme Q10, thiab kev tswj hwm qhov ncauj yuav ua tau zoo dua rau kev xa mus rau dermis, txhim kho daim tawv nqaij elasticity thiab firmness. Qhov kev pom zoo tam sim no ntau npaum li cas yog 30-150 mg/hnub.
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Kev lag luam kev zoo nkauj tau pom ib qho kev loj hlob ntawm kev koom nrog cov khoom xyaw ntuj thiab kev tshawb fawb pov thawj. Ntawm cov no, fermented compounds tau txais kev saib xyuas zoo vim lawv cov txiaj ntsig zoo rau cov tawv nqaij noj qab haus huv thiab zoo li.
Kev koom ua ke ntawm fermented astaxanthin, lycopene, beta-carotene, thiab Coenzyme Q10 hauv cov khoom lag luam zoo nkauj nthuav tawm lawv lub peev xwm loj heev los txhim kho cov tawv nqaij noj qab haus huv thiab zoo nkauj. Cov fermented compounds no muaj kev txhim kho bioavailability thiab kev ua tau zoo, tso cai rau kev nqus tau zoo dua thiab siv los ntawm daim tawv nqaij. Raws li qhov kev thov rau cov khoom xyaw ntuj thiab kev tshawb fawb tau nce ntxiv, cov khoom fermented ua pov thawj los ua ib qho tseem ceeb ntxiv rau kev lag luam kev zoo nkauj, muab cov neeg siv khoom zoo thiab muaj txiaj ntsig zoo.
Xav tau cov qauv dawb, thov hu rau peb cov kws tshaj lij ntawmsales@healthfulbio.com.