Conjugated linoleic acid (CLA) yog ib qho isomer ntawm linoleic acid. Nws yog ib tug series ntawm positional thiab geometric isomers ntawm linoleic acid nrog ob daim ntawv cog lus ntawm carbon 9, 11, los yog 10, 12. Nws yog ib tug tshiab functional fatty acid. Siv cov zaub mov-qib safflower noob roj ua raw khoom, cov linoleic acid nyob rau hauv nws yog hloov mus rau hauv conjugated linoleic acid los ntawm ib tug conjugation cov tshuaj tiv thaiv, uas yog ib tug ntxiv resource. Conjugated linoleic acid siv cov zaub mov-qib lipase ua cov khoom siv rau esterify conjugated linoleic acid fatty acids nrog glycerol los tsim conjugated linoleic acid glyceride.
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CLA tau txais GRAS (feem ntau lees paub tias muaj kev nyab xeeb) ntawv pov thawj los ntawm US FDA thiab raug suav tias yog cov khoom siv ntuj tsim, tsis ua rau khaus khaus uas tuaj yeem siv nyab xeeb hauv cov khoom noj thiab dej haus. Hauv xyoo 2008, FSANZ (Food Standards Australia New Zealand) tau lees paub CLA ua cov khoom noj tshiab. Thaum Lub Ib Hlis 2009, Kaus Lim Kauslim KFDA tau tsim CLA cov qauv thiab cov lus qhia tshwj xeeb. Lub Plaub Hlis 2010, European Union EFSA tshaj tawm tias CLA muaj kev nyab xeeb rau kev siv khoom noj.
CLA yog ib qho tseem ceeb fatty acid (tsis tuaj yeem tsim los ntawm tib neeg lub cev) thiab koom nrog omega -6 tsev neeg. Conjugated linoleic acid (glyceride) feem ntau tshwm raws li lub teeb daj oily kua. Nws yog lwm cov khoom siv lipid uas muaj txiaj ntsig zoo tom qab DHA thiab EPA.
Kev ua tau zoo ntawm CLA
1. Kev txo rog
Kev tshawb fawb txog kev ua haujlwm ntawm conjugated linoleic acid tau tsom rau kev txo cov rog. Conjugated linoleic acid tau pom tias cuam tshuam rau receptors lub luag haujlwm rau kev nce rog-hlwb thiab qabzib thiab lipid (rog) metabolism. Conjugated linoleic acid yuav ua lub luag haujlwm hauv inhibiting lipoprotein lipase (LPL), ib qho enzyme koom nrog hauv lipid metabolism (hloov cov rog mus rau adipocytes, thiab chaw cia khoom). Los ntawm kev txo cov haujlwm ntawm cov enzyme no, CLA ua rau txo qis hauv kev cia ntawm lub cev rog (triglycerides).
Qhov thib ob, nws yuav ua lub luag haujlwm hauv kev ua kom lipolysis, qhov tshwm sim uas lipids tau degraded thiab tom qab ntawd tso tawm ua cov roj ntsha fatty acids thiab siv los tsim lub zog (hlawv). Raws li nrog thawj qhov ua haujlwm, qhov txheej txheem no ua rau txo qis hauv triglycerides xauv hauv cov roj cia cell. Thaum kawg, kev tshawb fawb qhia tias CLA koom nrog hauv kev ua kom lub cev metabolism hauv cov rog rog. CLA tuaj yeem pab txo cov rog tsis poob, qhia tias nws tuaj yeem hlawv rog lub cev thaum khaws cov nqaij ntshiv.
Kev sim tshuaj ntsuam xyuas tau ua pov thawj tias conjugated linoleic acid muaj cov nyhuv txo qis, tshwj xeeb tshaj yog rau ob txhais ceg thiab lub duav.
2. Txo cov ntshav lipids thiab txhim kho vascular noj qab haus huv
Raws li daim ntawv pov thawj txawv teb chaws, CLA tuaj yeem ua lub luag haujlwm ntawm "vascular scavenger", tshem cov khib nyiab ntawm cov hlab ntsha, thiab tswj cov ntshav viscosity zoo. Raws li cov ntaub ntawv sau tseg, safflower muaj cov txiaj ntsig ntawm kev txhawb cov ntshav ncig, ua kom cov ntshav tsis txaus, txo qhov mob, tswj hwm endocrine, thiab tshem tawm cov dawb radicals. Nws cov noob - safflower noob (qhov chaw ntawm CLA) yog nplua nuj nyob rau hauv fatty acids tseem ceeb rau tib neeg lub cev. Kev siv mus sij hawm ntev muaj kev kho mob lub cev xws li txo cov ntshav lipids, txo cov ntshav siab, thiab ua kom cov roj cholesterol. Hauv cov neeg xeem, 0.7-1.4g CLA tau ntxiv txhua hnub. Tom qab 4 lub lis piam, lub cev rog cov ntsiab lus, cov ntshav triglycerides, thiab cov roj cholesterol tag nrho poob qis. Raws li cov txiaj ntsig tau tshaj tawm hauv lub rooj sib tham txhua xyoo ntawm American Chemical Society thaum Lub Yim Hli 2000, cov neeg mob uas muaj ntshav qab zib hom 2 uas tau ntxiv lawv cov zaub mov nrog 6g CLA txhua hnub rau 8 lub lis piam tuaj yeem txo cov qib triglyceride thiab txhim kho insulin secretion. Nws qhia tias CLA tuaj yeem muaj txiaj ntsig los tiv thaiv kev mob atherosclerosis thib ob hauv cov neeg mob ntshav qab zib hom 2.
3. Txhim khu kev tiv thaiv
Muaj ntau cov kev tshawb fawb hauv CLA ntawm kev tiv thaiv kab mob thiab kev tshawb fawb tsawg dua ntawm cov pej xeem. Lub tshuab yog tsuas yog los tswj cov kab mob inflammatory los ntawm inducing lipid peroxidation. CLA txhim kho kev tiv thaiv kab mob hauv cov lus hauv qab no: tswj cov qog necrosis factor- , cytokines (interleukin 1, 4, 6, 8), prostaglandins, los yog nitric oxides thaum txo cov tshuaj tiv thaiv kab mob. Cov kev tshawb fawb soj ntsuam tsis ntev los no tau pom tias CLA supplementation ntawm 6g CLA ib hnub twg rau 12 lub lis piam hauv cov neeg mob rheumatoid mob caj dab tuaj yeem txo qis kev tsim cov tshuaj tiv thaiv xws li TNF- lossis nuclear factor-kB (NFκB).
Los ntawm cov haujlwm saum toj no, nws tuaj yeem pom tias muaj ntau qhov cuam tshuam ntawm conjugated linoleic acid, xws li rog poob thiab txhim kho kev tiv thaiv kab mob, tuaj yeem ua lub luag haujlwm hauv kev ua kis las, tab sis nws tsis tuaj yeem siv rau hauv cov khoom noj khoom haus kis las. Raws li cov khoom noj khoom haus tshiab, nws txoj haujlwm ntawm daim ntawv thov muaj cov cai tswj xyuas meej. Txoj kev siv tsis suav nrog cov khoom noj khoom haus kis las lossis cov khoom noj tshwj xeeb.
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Kev siv ntawm CLA
Vim nws muaj ntau yam physiological functions thiab cov teebmeem, conjugated linoleic acid yog dav siv nyob rau hauv ntau lub teb.
Ua ntej ntawm tag nrho cov, nyob rau hauv lub teb ntawmnoj qab haus huv, conjugated linoleic acid tuaj yeem muab ntxiv rau ntau yam khoom noj, xws li cov khoom noj siv mis, kua txiv hmab txiv ntoo, khoom noj qab haus huv, thiab lwm yam, kom lawv cov khoom noj muaj txiaj ntsig thiab kev ua haujlwm. Qhov sib ntxiv ntawm CLA tsis tsuas yog ua kom cov khoom noj muaj txiaj ntsig zoo xwb tab sis kuj pab tib neeg nqus cov roj fatty acid tseem ceeb no kom tau raws li lub cev kev noj qab haus huv.
Thib ob, conjugated linoleic acid kuj tau siv dav hauv covchaw kws tshuaj. Nws tuaj yeem siv los ua ib qho immunomodulator thiab muaj cov ntawv thov dav dav. Ntau cov kev tshawb fawb tshawb fawb tau ua pov thawj tias CLA muaj ntau yam tseem ceeb ntawm lub cev muaj zog xws li antioxidants, txo cov roj cholesterol thiab triglycerides, thiab tiv thaiv atherosclerosis. Cov haujlwm no ua rau nws muaj peev xwm loj hauv kev kho mob.
Tsis tas li ntawd, conjugated linoleic acid kuj tseem muaj cov txiaj ntsig tseem ceeb hauv daim teb ntawmkev zoo nkauj thiab kev kho mob. Nws tuaj yeem siv los tsim cov khoom zoo nkauj thiab kev noj qab haus huv, xws li cov khoom tu tawv nqaij, cov khoom poob phaus, thiab lwm yam. CLA zoo ib yam li cov fatty acids secreted los ntawm tib neeg lub cev nqaij daim tawv, pab txhim kho daim tawv nqaij zoo thiab zoo lub cev nkhaus. Nws tuaj yeem tsis tsuas yog moisturize ntawm daim tawv nqaij thiab tiv thaiv nws los ntawm ib puag ncig kev puas tsuaj tab sis kuj txhim kho daim tawv nqaij elasticity thiab luster, uas qhia txog kev tiv thaiv kev laus. Tib lub sijhawm, CLA tseem tuaj yeem tiv thaiv thiab kho cov tawv nqaij puas thiab ntau yam kab mob ntawm daim tawv nqaij.
Ntxiv nrog rau daim ntawv thov saum toj no, conjugated linoleic acid kuj tuaj yeem siv los ua tsiaj pub ntxiv los txhim kho tsiaj kev loj hlob, nqaij zoo, thiab kev tiv thaiv.
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Conjugated linoleic acid los ntawm HSF Biotech
HSF yog lub tuam txhab tshwj xeeb hauv kev tsim cov linoleic acid conjugated. Peb cov khoom CLA tej zaum yuav haum rau ntau yam xws li khoom noj khoom haus, khoom noj khoom haus, khoom noj khoom haus, thiab lwm yam. Txawm hais tias nws yog ib tug neeg poob phaus, ib tug neeg nyiam noj qab haus huv, los yog cov neeg laus, peb cov khoom CLA tuaj yeem pab txhawb kev noj haus.
Yog xav paub ntxiv, thov hu rau peb:
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