Cov txiaj ntsig ntawm niacinamide yog dab tsi?

Qhov chaw ntawm niacinamide

Niacinamide, tseem hu ua vitamin B3, yog ib qho tseem ceeb derivative ntawm niacin thiab yog dav faib nyob rau hauv ntau yam zaub mov nyob rau hauv cov xwm. Los ntawm cov khoom noj tsiaj ntau xws li nqaij (tshwj xeeb tshaj yog daim siab), ntses, nqaij qaib, thiab cov khoom noj siv mis, rau cog zaub mov xws li avocados, tag nrho cov nplej (bob nplej, oats), nceb, thiab zaub nplooj ntsuab, txhua yam muaj cov khoom noj ntawm B3. Cov khoom xyaw ntuj no txaus siab rau peb txoj kev nrhiav kev noj qab haus huv thiab pom tsis pom lub cev nrog B3 muaj nuj nqis. Txawm hais tias tib neeg lub cev muaj peev xwm tsim tau ib qho me me ntawm Niacinamide los ntawm txoj kev metabolic ntawm tryptophan, nws cov txiaj ntsig tau txwv thiab nws tsis yooj yim kom tau raws li cov kev xav tau niaj hnub no. Yog li ntawd, kev noj zaub mov kom zoo dhau los ua tus yuam sij kom tau txais cov khoom noj tseem ceeb no.

Kev hloov pauv ntawm Nicotinamide thiab NAD +

Hauv tib neeg lub cev, nicotinamide tau dhau los ua kev hloov pauv biochemical zoo nkauj, hloov mus rau NAD + (nicotinamide adenine dinucleotide). Qhov kev hloov pauv no tsis tsuas yog qhib tus yuam sij rau cellular zog metabolism tab sis kuj ua rau NAD + lub luag haujlwm tseem ceeb hauv lub neej ua haujlwm. Raws li lub catalyst rau lub zog tsim cov txheej txheem xws li lub voj voog tricarboxylic acid thiab oxidative phosphorylation, NAD + tsis tsuas yog tsav lub zog ntawm tes, tab sis kuj koom nrog kev koom tes hauv cov txheej txheem tseem ceeb hauv lub neej xws li kho cell, DNA synthesis, thiab noob qhia. Nws yog lub hauv paus ntawm kev tswj cov cell noj qab haus huv thiab tseem ceeb.

Cov teebmeem ntawm niacinamide

Txij li thaum cov kws tshawb fawb Askiv tau tshawb pom thawj zaug ntawm daim ntawv thov ntawm niacinamide hauv kev tiv thaiv hnub ci hauv xyoo 1974, nws cov txiaj ntsig zoo ntawm cov tawv nqaij tau maj mam dhau los ua neeg ntiaj teb. Thaum pib, niacinamide nyiam ntau xim vim nws lub peev xwm los cuam tshuam kev hloov ntawm melanin mus rau keratinocytes. Niacinamide tuaj yeem ua kom cov metabolism hauv cov hlwb ntawm daim tawv nqaij thiab txhawb kev tsim thiab rov ua dua tshiab ntawm collagen, yog li txhim kho cov cim ntawm kev laus xws li tawv nqaij sagging thiab wrinkles.

Ntxiv nrog rau nws cov kev paub zoo ntawm kev tu tawv nqaij, niacinamide kuj tau pom muaj peev xwm zoo hauv kev noj qab haus huv.

Niacinamide thiab kev laus

Niacinamide qib txo qis thaum muaj hnub nyoog, uas qhia tau hais tias nws yog ib qho tseem ceeb rau kev ua haujlwm metabolic thiab cov kab mob uas muaj hnub nyoog. DNA puas tsuaj accumulates thiab snowballs nrog hnub nyoog. Cov kev sim tau pom tias kev tswj hwm qhov ncauj ntawm 1000mg ntawm niacinamide ib hnub hauv cov neeg laus hnub nyoog 70-80 tuaj yeem nce qib ntawm niacinamide metabolism hauv cov leeg, yog li txo cov leeg nqaij hauv cov neeg laus thiab txo cov qib ntawm cov kab mob cytokines.

Nicotinamide thiab kab mob neurological

Raws li ib tug muaj peev xwm neuroprotective agent, nicotinamide yog ib feem ntawm cov neurotransmitters NAD (nicotinamide adenine dinucleotide) thiab NADP (nicotinamide adenine dinucleotide phosphate), uas yog ib qho tseem ceeb nyob rau hauv lub paj hlwb. Ua lub luag haujlwm tseem ceeb hauv nws txoj haujlwm ib txwm muaj. Lawv koom nrog cov tshuaj tiv thaiv redox hauv lub cev thiab muab lub zog rau cov metabolism hauv cell, yog li txhawb kev ua haujlwm ntawm lub paj hlwb. Nicotinamide tam sim no tab tom tshawb nrhiav los txhim kho ntau yam kab mob neurodegenerative. Kev txhim kho nicotinamide ntxiv tuaj yeem pab txhim kho ntau yam txheej txheem tseem ceeb uas cuam tshuam nrog kev tsim cov kab mob Parkinson, suav nrog mitochondrial ua pa tsis ua haujlwm, neuroinflammation, epigenomic dysregulation, thiab nce neural DNA puas. Tam sim no, ntau qhov kev sim tshuaj ntsuam xyuas qhov cuam tshuam ntawm nicotinamide supplementation hauv cov neeg mob Parkinson's disease.

Niacinamide thiab rog rog

Nicotinamide tseem ua si ntau lub luag haujlwm hauv lub zog metabolism, kho cell, thiab kev qhia cov noob. Kev tshawb fawb qhia tau hais tias nyob rau hauv cov txiv neej noj qab haus huv los yog rog rog, supplementation nrog 1000 mg / hnub ntawm nicotinamide (los yog nws active daim ntawv xws li NR, nicotinamide ribose) rau 6 lub lis piam nce NAD + metabolism hauv tib neeg skeletal leeg NAAD (N-acetyl adenosine diphosphate. ) thiab MeNAM (N-methyl nicotinamide) qib. Qhov nce hauv cov metabolites no qhia txog kev ua kom NAD + metabolic txoj hauv kev, uas tuaj yeem txhawb lub zog metabolism thiab fatty acid oxidation hauv cov leeg pob txha. Qhov tseem ceeb, NR supplementation kuj tau pom los ua kom pw tsaug zog metabolic. Pw tsaug zog metabolic rate yog hais txog tus nqi uas lub cev siv zog thaum pw tsaug zog. Los ntawm kev nce kev pw tsaug zog metabolic, niacinamide supplementation tuaj yeem pab txuas ntxiv hlawv calories thaum hmo ntuj, txhawb kev poob phaus ntxiv. Qhov kev tshawb pom no muab qhov kev xav tshiab ntawm kev tswj kev rog los ntawm kev ua kom lub zog metabolism thaum pw tsaug zog los pab kom poob phaus.

Nicotinamide thiab kab mob plawv

NAD + ua lub luag haujlwm tseem ceeb hauv cellular zog metabolism, redox tshuaj tiv thaiv, thiab kho DNA. Tsawg NAD + qib muaj feem cuam tshuam nrog cov kab mob ntawm ntau yam kab mob plawv. Los ntawm kev ntxiv NAD + precursors xws li nicotinamide, intracellular NAD + qib tuaj yeem nce ntxiv, yog li txhim kho lub plawv txoj haujlwm thiab muaj peev xwm tiv thaiv kev puas tsuaj. Nicotinamide, ua tus thawj coj ntawm NAD +, nthuav tawm cov kev tiv thaiv tseem ceeb hauv cov kab mob plawv los ntawm kev nce qib NAD + hauv lub cev. Tsis tas li ntawd, nicotinamide muaj cov nyhuv antioxidant tseem ceeb, uas tuaj yeem tshem tawm cov dawb radicals ntawm cov hlab ntsha phab ntsa thiab txo qhov kev puas tsuaj ntawm cov dawb radicals rau cardiomyocytes. Cov nyhuv antioxidant no pab tiv thaiv cov txheej txheem thiab kev ua haujlwm ntawm lub plawv hlwb thiab txo qhov kev pheej hmoo ntawm kab mob plawv.

Dawb crystalline hmoov los yog dawb koob-zoo li tus muaju, tsw los yog yuav luag tsis muaj ntxhiab, iab, me ntsis hygroscopic.

Rau cov neeg xav paub txog niacinamide hmoov thiab nws cov ntawv thov hauv kev lag luam sib txawv, suav nrog biotechnology thiab kev tsim khoom noj, mus tom ntej thiab tiv tauj peb ntawmsales@healthfulbio.com.Peb pab pawg ntawm HSF Biotech siv lub sijhawm tseem ceeb hauv kev tsim cov niacinamide hmoov zoo, lav ruaj khov thiab tsis muaj zog. Peb cov niacinamide hmoov yog cov khoom zoo, dawb translucent nrog ib tus ntxhiab tsw. Nws yog qhov tshwj xeeb tshaj plaws nyob rau hauv dej thiab ruaj khov nyob rau hauv lub peev xwm zoo tib yam, ua rau nws tsim nyog rau kev siv ntau hauv cov khoom noj, tshuaj, thiab kev kho ventures.