Puas yog CoQ10 pab nrog osteoporosis?

Osteoporosis (OP) yog ib qho kab mob uas ua rau cov pob txha metabolism tsis zoo. Lub Koom Haum Saib Xyuas Kev Noj Qab Haus Huv (World Health Organization) txhais tias nws yog pob txha pob txha pob txha ntom ntom (BMD) uas yog 2.5 tus qauv sib txawv lossis ntau dua qis dua qhov nruab nrab BMD ntawm cov tub ntxhais hluas cov neeg mob noj qab haus huv. Kev tshawb fawb txog kab mob kis tau pom tias qhov tshwm sim ntawm poj niam OP nce nrog lub hnub nyoog, thiab cov poj niam muaj hnub nyoog tshaj 65 xyoo yog 51.6%. Tus nqi ntawm cov pob txha resorption nyob rau hauv cov poj niam postmenopausal yog hais txog ob zaug ntawm cov pob txha tsim, uas muaj feem xyuam rau kev txo qis ntawm zes qe menyuam muaj nuj nqi, oxidative kev nyuaj siab, nce qib ntawm inflammatory yam tseem ceeb, thiab hloov pauv hauv estrogen thiab follicle-stimulating hormone (FSH).

Txawm hais tias exogenous estrogen therapy tuaj yeem txo qhov tshwm sim ntawm postmenopausal osteoporosis (PMOP), kev siv cov tshuaj estrogen mus sij hawm ntev tuaj yeem ua rau muaj qhov tshwm sim ntawm lwm yam kab mob thiab kev kho mob ntawm lwm cov tshuaj tiv thaiv OP yuav raug txwv. vim lawv cov kev mob tshwm sim.

Coenzyme Q10feem ntau yog siv los txhim kho zes qe menyuam muaj nuj nqi thiab txhim kho fertility hauv kev kho mob ntawm gynecological kab mob vim nws cov antioxidant zog. Nyob rau hauv xyoo tas los no, kev tshawb fawb tau pom tias coenzyme Q10 kuj muaj kev ua tau zoo thiab kev nyab xeeb hauv kev kho OP.

Cov qauv thiab kev ua haujlwm ntawm coenzyme Q10

Coenzyme Q10 yog lub lipophilic electron cab kuj koom tes nyob rau hauv kev hloov ntawm electron chains thiab yog lub hauv paus ntawm cell metabolism. Raws li ib txwm muaj, nws muaj nyob hauv lub cev hauv ob hom: redox. Feem ntau ntawm coenzyme Q10 xav tau los ntawm tib neeg lub cev yog tsim los ntawm nws cov ntaub so ntswg. Tom qab hnub nyoog 25 xyoos, cov ntsiab lus ntawm coenzyme Q10 hauv tib neeg lub cev yuav txo qis thaum muaj hnub nyoog. Kev sib txuas tas mus li ntawm cov pa oxygen reactive (ROS) hauv cov poj niam lub cev yuav maj mam nce qhov kev pheej hmoo ntawm OP. Nyob rau hauv thaum ntxov hnub, coenzyme Q10 feem ntau dav txhawb raws li kev noj haus ntxiv. Nws tau siv rau hauv kev kho mob ntawm ntau yam kab mob, xws li ntshav qab zib, Parkinson's syndrome, txiv neej asthenospermia, ntxov ntxov ntxov ntawm zes qe menyuam tsis ua hauj lwm, kab mob plawv, thiab lwm yam. Raws li kev kho mob daim ntawv thov ntawm coenzyme Q10 tau nrov, nws cov haujlwm tshiab kuj tau pib tshawb nrhiav. Coenzyme Q10 muaj kev tshawb fawb tseem ceeb hauv kev kho PMOP, tab sis lub peev xwm ntawm kev ua haujlwm xav tau kev tshawb nrhiav ntxiv.

Mechanism ntawm Coenzyme Q10 hauv kev kho mob Postmenopausal Osteoporosis

1. Kev rog dhau ua rau cov qib Testosterone tsawg

Estrogen deficiency nyob rau hauv cov poj niam postmenopausal muaj peev xwm inhibit qhov oxidation ntawm mitochondrial -fatty acids nyob rau hauv lub cev lub hlwb thiab ua rau kom zus tau tej cov pa dawb radicals. ROS-induced pob txha poob yog feem ntau tshwm sim los ntawm RANKL. Tom qab lub cev tsis muaj zog, qib RANKL nyob rau hauv cov pob txha microenvironment yuav nce vim qhov tsis muaj tshuaj estrogen, thiab qhov nce hauv FSH concentration yuav txhim kho T cell activation. Cov activated T hlwb yuav ua rau RANKL-induced osteoclast activation thiab pob txha puas. Coenzyme Q10, tseem hu ua ubiquitin ketone, yog yooj yim soluble nyob rau hauv lipid kuab tshuaj thiab muaj zoo kam rau ua thiab kev nyab xeeb. Hauv kev kho PMOP, Coenzyme Q10 tuaj yeem hloov cov tshuaj estrogen los tua oxidative kev nyuaj siab thiab inhibit qhov tsim ntawm RANKL-induced osteoclasts. Tsis tas li ntawd, Coenzyme Q10 tseem tuaj yeem tshem tawm cov pa oxygen dawb radicals hauv cov cell ncaj qha thiab tiv thaiv cov pob txha.

2. inhibit qhov kev qhia ntawm inflammatory yam

Inflammation yog ib qho kev tiv thaiv tus kheej ntawm cov hlwb rau cov teeb meem sab nraud stimuli, tab sis ntev ntev inflammatory tshwm sim los ntawm kev ntxhov siab tsis zoo tuaj yeem ua rau pob txha puas. Inflammatory cytokines ua lub luag haujlwm tseem ceeb hauv kev txhim kho PMOP hauv tib neeg thiab tsiaj cov qauv. Txhawm rau tiv thaiv PMOP zoo, ntxiv rau kev nce qib ntawm cov tshuaj estrogen hauv lub cev, nws tseem ceeb heev rau inhibit qhov kev qhia ntawm inflammatory yam. Coenzyme Q10 zoo ib yam li ntau cov tshuaj antioxidants thiab muaj peev xwm tiv thaiv kab mob. "Anti-inflammatory" yog tiag tiag "anti-oxidation" rau qee qhov. Coenzyme Q10 tuaj yeem qhib txoj hauv kev uas muaj qhov cuam tshuam nuclear E2- cuam tshuam txog 2 (Nrf2) nyob, qhib cov enzymes hauv qab ntawm txoj hauv kev los tawm tsam oxidative kev nyuaj siab thiab inhibit qhov kev qhia ntawm inflammatory yam.

3. Tswj cov apoptosis ntawm RAW264.7 cell mitochondria

RAW264.7 hlwb yog ib qho ntawm cov neeg hauv tsev neeg ntawm cov kab mob mononuclear / macrophage thiab tuaj yeem sib txawv rau hauv cov cell multinuclear nrog lub peev xwm osteoclast. Cov cell no zoo ib yam li cov macrophages feem ntau thiab tuaj yeem phagocytose cell fragments thiab haus cov kab mob. Nyob rau hauv cov txheej txheem ntawm cov pob txha ib txwm metabolism ntawm cov poj niam, RAW264.7 tuaj yeem acidify pob txha, degrade collagen, thiab txhawb cov pob txha kho. Thaum tsis muaj kev tawm dag zog sab nraud, RAW264.7 hlwb tsuas yog proliferate. Txawm li cas los xij, qhov poob ntawm cov tshuaj estrogen hauv cov poj niam postmenopausal nce, ua rau RAW264.7 sai sai sib txawv rau hauv osteoclasts paub tab, ua rau muaj qhov txawv txav ntawm cov osteoclasts ntau ntxiv thiab qhov tsis txaus ntseeg hauv cov pob txha metabolism. Coenzyme Q10 tuaj yeem txhim kho qhov kev qhia ntawm mitochondrial apoptosis cov proteins hauv RAW264.7 hlwb txhawm rau tiv thaiv kev tsim cov osteoclasts thiab xav tias yuav dhau los ua cov tshuaj sib tw rau kev kho PMOP yav tom ntej.

4. Txo cov ntshav FSH ntau ntau

Tom qab lub cev tsis muaj zog, cov poj niam raug kev txom nyem cov pob txha loj tshaj plaws, thiab cov qib FSH cov ntshav yuav nce sai thiab tswj tau qib siab rau ntau xyoo. Qhov txo qis hauv cov tshuaj estrogen tsis muaj zog ua rau cov nyhuv inhibitory ntawm hypothalamus-pituitary axis, ua rau muaj kev nce hauv FSH concentration, ua rau tsis muaj zog osteoblast kev ua haujlwm, active osteoclast sib txawv, thiab txuas ntxiv nce hauv pob txha resorption. Coenzyme Q10 tuaj yeem thim rov qab cov ntshav FSH concentration hauv cov poj niam laus, yog li nws tau xav tias coenzyme Q10 tuaj yeem kho PMOP los ntawm kev txo cov ntshav FSH. Nyob rau hauv lub neej yav tom ntej, cov ncauj lus kom ntxaws mechanism ntawm kev txiav txim ntawm coenzyme Q10 hauv kev txo FSH los kho PMOP tuaj yeem kawm txog qhov tob ntawm qhov kev xav ntawm molecular biology.

Thaum kawg, PMOP cuam tshuam nrog kev laus ntawm zes qe menyuam ua haujlwm thiab hloov pauv ntawm cov tshuaj hormones hauv lub cev. Estrogen tsis muaj peev xwm thiab nce FSH yog qhov tseem ceeb uas ua rau muaj qhov nce ntawm cov kab mob inflammatory thiab ROS, uas nyob rau hauv lem indirectly induce RAW264.7 hlwb kom sib txawv rau hauv osteoclasts. Ntau yam kev tshawb fawb tsiaj tau pom tias coenzyme Q10 tuaj yeem tsis tsuas yog txhim kho OP los ntawm ntau txoj hauv kev, tab sis kuj tseem pab kho lub zes qe menyuam, thiab nws txoj kev nyab xeeb yog siab dua lwm cov tshuaj tiv thaiv OP hauv kev kho mob. Txawm li cas los xij, txog tam sim no, feem ntau ntawm cov txheej txheem kev kho mob ntawm coenzyme Q10 rau PMOP feem ntau yog cov kev tshawb fawb tsiaj, thiab cov kev tshawb fawb soj ntsuam tsis tshua muaj; qee qhov kev txiav txim siab ntawm kev sim tsiaj kuj tau kos los ntawm kev kwv yees, uas xav tau kev txheeb xyuas ntxiv thiab tshawb nrhiav.

HSF Biotech's Coenzyme Q10

Txhawm rau txhim kho bioavailability ntawm Coenzyme Q10, nws yog ib qho tseem ceeb uas yuav tsum xaiv cov qauv tsim nyog raws li cov kev xav tau sib txawv, ua kom muaj kev tso tawm zoo dua thiab ua haujlwm hauv lub cev. Kev vam khom ntawm peb qhov kev sib cais thiab kev siv tshuab thev naus laus zis, HSF Biotech tsim Coenzyme Q10 siv cov dej txias dispersion microencapsulation tshuab. Qhov no ua kom ruaj khov kev ua haujlwm, kev tswj xyuas nruj ntawm cov kab paug paug, thiab cov dej ntws zoo. Nws sai sai disperses nyob rau hauv dej txias, ua rau nws haum rau ntau yam kev siv xws li cov dej haus, gummies, thiab premixes. Nws tuaj yeem ua ke nrog cov vitamin E / cov roj cog thiab siv dav hauv cov khoom noj khoom haus thiab cov tshuaj ntsiav, ntawm lwm yam khoom.

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